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This book teaches biochemists and molecular biologists in a hands-on fashion the use of modern computational methods for the analysis of complex biomedical systems; a modest mathemati-cal background will suffice. The book begins with representations of biochemical systems, provides guidelines for setting up models,discusses in detail mathematical and computational methods of pa-rameter estimation and model analysis, and ultimately connects to the modern literature with four detailed case studies. Every step is illustrated with examples and exercises, and is explored with the ac-companying software, PLAS. A dedicated Web site featuring color illustrations, further exercises, research news, as well as resources and links also accompanies this book.

Prejace
Introduction
1 Graphical Representation of Biochemical Systems
2 Models of Biochemical Systems
3 From Maps to Equations
4 Computer Simulation
6 Analytical Steady State Evaluation
7 Sensitivity Analysis
8 Case Study 1-Anaerobic Fermentation Pathway in Sacchammyces cerevisiae
9 Case Study 2-Diagnosis and Refinement of a Model of the Tricarboxylic Acid Cycle in Dictyostelium discoideum
10 Case Study 3-A Sequence of Models Describing Purlne Metabolism
11 Case Study 4-Algebraic Analysis of the Initial Steps of the Glycolytic-Glycogenoly tic Pathway in Per fused Rat Liver
12 Epilogue - Canonical Modeling Beyond Biochemistry
Appendix
Hints and Partial Solutions
References
Author Index
Subject Index